--- a/sound/usb/midi.c
+++ b/sound/usb/midi.c
@@ -1145,7 +1145,18 @@ static int snd_usbmidi_output_open(struc
 
 static int snd_usbmidi_output_close(struct snd_rawmidi_substream *substream)
 {
-	return substream_open(substream, 0, 0);
+	struct snd_usb_midi *umidi = substream->rmidi->private_data;
+	int i;
+	int ret = substream_open(substream, 0, 0);
+
+	for (i = 0; i < MIDI_MAX_ENDPOINTS; ++i) {
+		struct snd_usb_midi_endpoint *ep = &umidi->endpoints[i];
+
+		/* cancel work for the individual runtime */
+		if (ep->out)
+			cancel_work_sync(&ep->out->work);
+	}
+	return ret;
 }
 
 static void snd_usbmidi_output_trigger(struct snd_rawmidi_substream *substream,